![]() ![]() Certain cards and runes, such as V - The Hierophant, VI - The Lovers, VII - The Chariot, XIX - The Sun, Rune of Algiz, and Rune of Dagaz, can also act as health regeneration or protection to counteract the timed damage or the increased difficulty in general. Blank Card is a powerful item in this run, as there are cards and runes such as IV - The Emperor, XIX - The Sun, Rune of Ansuz, and Rune of Ehwaz, all of which can enable faster progression through the game. ![]() Items that generate health or protection thus help greatly, These include The Wafer, Cancer, Yum Heart, Unicorn Stump, Prayer Card, and many many more. Not only will health compensate for the damage taken, be it from the more difficult rooms/bosses or the timed damage, but it can also be used for Devil Deals to access its high DPS item pool. Health is always important, but even more so in this challenge.Note that the time limit is not a "hard" one and that the game is not over when the countdown timer reaches 0 however, from that point onwards Isaac will start taking half a heart of damage every 10 seconds, or a full heart of damage starting from chapter 4. More importantly, the 16-minute soft time limit is also very hard to beat and may force the player to forget exploring for rewards that might have helped them later on. Firstly, the increased speed for both the enemies and Isaac can make most routine rooms and bosses challenging. This is arguably one of the hardest challenges in the game, for two major reasons. ![]()
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